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KMID : 0043319930160040283
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Archives of Pharmacal Research
1993 Volume.16 No. 4 p.283 ~ p.288
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Evaluation of Some Flavonoids as Potential Bradykinin Antagonists
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Choi Hye-Sook
Chung Sung-Hyun
Kim Young-Joo
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Abstract
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Fourteen flavonoids were evaluated for their effects as potential bradykinin (BK) antagonists. The compounds were evaluatd in several in vitro and in vivo (oral administration) systems ; inhibition of BK induced contractions in isolated rat ileum and uterus, antagonistic effects of BK induced plasma extravasation, reduction of acetic acid induced withing nociception and protection from endotoxic shock. Skullcapflavone II (3), baicalein (5), 5-methoxyflavone (11), 6-methoxyflavone (12) and 2’-methoxyflavone (14) showed effects in all the tests although the order of potency were somewhat varied.
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KEYWORD
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Potential bradykinin (BK) antagonists, Skullcapflavone ll, Baicalein, 5-Methoxyflavone, 6-Methoxyflavone, 2’-Methoxyflavone
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